Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.006


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_1706688920.683.4e-03Click!
TLX1chr10_+_1028810500.391.4e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_54392328 4.278 NM_001144997
 ITGA7
integrin, alpha 7
chr2_-_217268492 4.240 NM_000599
 IGFBP5
insulin-like growth factor binding protein 5
chr12_+_13240868 3.334 NM_001423
 EMP1
epithelial membrane protein 1
chr12_+_13240987 3.107 EMP1
epithelial membrane protein 1
chrX_-_128616594 2.957 NM_017413
 APLN
apelin
chrX_-_53327473 2.827 NM_015075
 IQSEC2
IQ motif and Sec7 domain 2
chr14_+_85066265 2.772 FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_38417564 2.725 C15orf52
chromosome 15 open reading frame 52
chr14_+_85066207 2.644 NM_013231
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_38420414 2.611 NM_207380
 C15orf52
chromosome 15 open reading frame 52
chr17_-_74487527 2.477 NM_005567
 LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr1_+_201862548 2.434 NM_001001396
NM_001684
 ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr11_-_3104413 2.414 OSBPL5
oxysterol binding protein-like 5
chr12_+_123339662 2.381 NM_181709
 FAM101A
family with sequence similarity 101, member A
chr22_+_44828338 2.362


chr15_-_38000379 2.340 NM_007223
 GPR176
G protein-coupled receptor 176
chr7_+_115952279 2.278 NM_001172895
 CAV1
caveolin 1, caveolae protein, 22kDa
chr21_-_27139563 2.197 NM_006988
 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_115952074 2.188 NM_001753
 CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_55808514 2.170 NM_002332
 LRP1
low density lipoprotein receptor-related protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.21 4.19e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
2.30 2.37e-04 GO:0005578 proteinaceous extracellular matrix
2.13 5.10e-04 GO:0031012 extracellular matrix
1.91 1.26e-02 GO:0043005 neuron projection
1.88 4.49e-08 GO:0044421 extracellular region part
1.79 1.24e-04 GO:0005615 extracellular space
1.54 1.57e-03 GO:0031226 intrinsic to plasma membrane
1.53 3.81e-07 GO:0044459 plasma membrane part
1.51 5.69e-03 GO:0005887 integral to plasma membrane
1.50 1.17e-05 GO:0005576 extracellular region
1.29 1.04e-04 GO:0005886 plasma membrane
1.29 1.25e-04 GO:0071944 cell periphery
1.13 4.07e-02 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 3 of 3 entries
enrichment   p-value GO term description
3.40 4.39e-02 GO:0030165 PDZ domain binding
2.64 5.65e-03 GO:0008083 growth factor activity
1.51 4.15e-02 GO:0005102 receptor binding