Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.006


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TLX3chr5_+_1706688920.683.4e-03Click!
TLX1chr10_+_1028810500.391.4e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_54392328 4.278 NM_001144997
ITGA7
integrin, alpha 7
chr2_-_217268492 4.240 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr12_+_13240868 3.334 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 3.107 EMP1
epithelial membrane protein 1
chrX_-_128616594 2.957 NM_017413
APLN
apelin
chrX_-_53327473 2.827 NM_015075
IQSEC2
IQ motif and Sec7 domain 2
chr14_+_85066265 2.772 FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_38417564 2.725 C15orf52
chromosome 15 open reading frame 52
chr14_+_85066207 2.644 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_38420414 2.611 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr17_-_74487527 2.477 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr1_+_201862548 2.434 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr11_-_3104413 2.414 OSBPL5
oxysterol binding protein-like 5
chr12_+_123339662 2.381 NM_181709
FAM101A
family with sequence similarity 101, member A
chr22_+_44828338 2.362


chr15_-_38000379 2.340 NM_007223
GPR176
G protein-coupled receptor 176
chr7_+_115952279 2.278 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr21_-_27139563 2.197 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr7_+_115952074 2.188 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_55808514 2.170 NM_002332
LRP1
low density lipoprotein receptor-related protein 1
chr17_+_74542066 2.122 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_-_24972471 2.016 NM_032854
CORO6
coronin 6
chr9_+_27099138 2.007 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr17_-_74433048 1.976 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr10_+_22580992 1.949


chr21_-_27139143 1.947 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr10_-_100164877 1.931 NM_032709
PYROXD2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr20_-_33489383 1.900 NM_000557
GDF5
growth differentiation factor 5
chr5_+_150000394 1.884 NM_001109974
NM_007286
SYNPO

synaptopodin

chr8_+_22078817 1.846 BMP1
bone morphogenetic protein 1
chr7_+_22733290 1.827 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chr7_-_123460722 1.822 NM_001136002
TMEM229A
transmembrane protein 229A
chr1_-_32036802 1.817 SPOCD1
SPOC domain containing 1
chr7_+_102340579 1.799 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr17_-_72045218 1.777 NM_134268
CYGB
cytoglobin
chr10_+_124310170 1.751 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr8_+_22078622 1.711 BMP1
bone morphogenetic protein 1
chr8_+_22078589 1.706 NM_001199
NM_006129
BMP1

bone morphogenetic protein 1

chr17_-_36396778 1.706 NM_182497
KRT40
keratin 40
chr8_-_22044463 1.667 NM_005144
NM_018411
HR

hairless homolog (mouse)

chr22_+_40093245 1.665 NM_001145398
TEF
thyrotrophic embryonic factor
chr6_+_39868770 1.656 NM_015345
DAAM2
dishevelled associated activator of morphogenesis 2
chr2_-_233586145 1.627 NGEF
neuronal guanine nucleotide exchange factor
chr11_-_65082208 1.608 NM_001130144
NM_001164266
NM_021070
LTBP3


latent transforming growth factor beta binding protein 3


chr12_-_50871953 1.595 NM_001081492
NM_182507
KRT80

keratin 80

chr17_-_39265965 1.587 NM_001932
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr22_-_44828636 1.567 NM_018280
C22orf26
chromosome 22 open reading frame 26
chr11_-_10671736 1.543 MRVI1
murine retrovirus integration site 1 homolog
chr11_-_10672079 1.540 NM_001100163
NM_130385
MRVI1

murine retrovirus integration site 1 homolog

chr20_-_60360789 1.538 LAMA5
laminin, alpha 5
chrX_+_99785818 1.524 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr2_+_97696462 1.494 NM_001079
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr1_+_201862845 1.494 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chrX_+_106048245 1.492 NM_001171095
CLDN2
claudin 2
chr9_-_25668855 1.490 NM_001004125
TUSC1
tumor suppressor candidate 1
chr11_-_65082705 1.481 LTBP3
latent transforming growth factor beta binding protein 3
chr17_-_40348378 1.477 NM_001131019
NM_002055
GFAP

glial fibrillary acidic protein

chr21_+_32706615 1.473 NM_058187
C21orf63
chromosome 21 open reading frame 63
chr11_-_10671873 1.471 MRVI1
murine retrovirus integration site 1 homolog
chr10_+_88708267 1.466 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr9_-_78710698 1.455 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr1_-_32054164 1.455 NM_144569
SPOCD1
SPOC domain containing 1
chr8_-_27525084 1.442 NM_001171138
CLU
clusterin
chr12_-_53099203 1.441 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr4_+_86968069 1.435 ARHGAP24
Rho GTPase activating protein 24
chr7_-_27153892 1.435 NM_024014
HOXA6
homeobox A6
chr1_-_159435440 1.431 NM_005099
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr1_-_151852128 1.407 NM_080388
S100A16
S100 calcium binding protein A16
chr4_-_66218777 1.386 EPHA5
EPH receptor A5
chr2_-_233586164 1.379 NM_019850
NGEF
neuronal guanine nucleotide exchange factor
chr11_-_85074848 1.369 NM_152723
CCDC89
coiled-coil domain containing 89
chr12_+_118100977 1.367 NM_014365
HSPB8
heat shock 22kDa protein 8
chr12_+_55808696 1.365 LRP1
low density lipoprotein receptor-related protein 1
chr9_-_129656778 1.311 ENG
endoglin
chr2_+_128009782 1.310 NM_001080527
MYO7B
myosin VIIB
chr20_+_58004811 1.308 NM_021810
CDH26
cadherin 26
chr1_-_32036858 1.298 SPOCD1
SPOC domain containing 1
chr3_-_58538110 1.281 FAM107A
family with sequence similarity 107, member A
chr19_+_7493436 1.280 NM_020533
MCOLN1
mucolipin 1
chr10_-_128067052 1.279 ADAM12
ADAM metallopeptidase domain 12
chr8_-_27524744 1.278 NM_203339
CLU
clusterin
chr16_-_2204776 1.253 NM_001042371
PGP
phosphoglycolate phosphatase
chr14_+_23937766 1.238 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr12_+_64504408 1.218 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr9_-_129656413 1.215 ENG
endoglin
chr10_+_17311242 1.201 VIM
vimentin
chr12_+_16397617 1.194 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr2_+_66516196 1.188 MEIS1
Meis homeobox 1
chr19_+_17440577 1.186 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr8_+_120497732 1.185 NM_002514
NOV
nephroblastoma overexpressed gene
chr1_+_151015471 1.176 NM_178354
LCE1F
late cornified envelope 1F
chr10_-_17311961 1.174


chr2_+_66516020 1.170 NM_002398
MEIS1
Meis homeobox 1
chr9_-_129656581 1.170 ENG
endoglin
chr1_+_201862552 1.152 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr9_-_112840064 1.150 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr1_+_213245507 1.144 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr12_-_53099269 1.137 ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr10_+_17311283 1.130 VIM
vimentin
chr9_+_135389698 1.127 NM_014694
ADAMTSL2
ADAMTS-like 2
chr10_-_128067001 1.126 ADAM12
ADAM metallopeptidase domain 12
chrX_+_149364377 1.123 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr7_+_22733626 1.120 IL6
interleukin 6 (interferon, beta 2)
chr9_-_25668230 1.113 TUSC1
tumor suppressor candidate 1
chr15_-_66511488 1.113 NM_001004439
ITGA11
integrin, alpha 11
chr7_+_115952325 1.112 CAV1
caveolin 1, caveolae protein, 22kDa
chr20_-_60375695 1.094 NM_005560
LAMA5
laminin, alpha 5
chr2_-_192419896 1.082 SDPR
serum deprivation response
chr10_+_17311307 1.081 VIM
vimentin
chr5_+_66160359 1.080 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr11_+_1200894 1.077 MUC5B
mucin 5B, oligomeric mucus/gel-forming
chr2_+_10360471 1.075 NM_002149
HPCAL1
hippocalcin-like 1
chr17_-_73867748 1.072 NM_003955
SOCS3
suppressor of cytokine signaling 3
chr10_+_17311282 1.072 VIM
vimentin
chr18_-_53621277 1.070 NM_005603
ATP8B1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr16_+_2025922 1.066 SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr10_+_17311347 1.055 VIM
vimentin
chr7_+_100557098 1.051 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr1_+_116181927 1.050 NHLH2
nescient helix loop helix 2
chr1_-_41722883 1.049 NM_001956
EDN2
endothelin 2
chrX_+_99786044 1.046 SRPX2
sushi-repeat containing protein, X-linked 2
chr20_+_8997791 1.046 PLCB4
phospholipase C, beta 4
chr11_+_46679140 1.044 NM_001184751
ZNF408
zinc finger protein 408
chr2_-_216008689 1.039 FN1
fibronectin 1
chr7_-_81237162 1.036 NM_000601
NM_001010931
NM_001010932
NM_001010933
NM_001010934
HGF




hepatocyte growth factor (hepapoietin A; scatter factor)




chr11_-_6298284 1.035 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr9_-_35860316 1.029 NM_001004487
OR13J1
olfactory receptor, family 13, subfamily J, member 1
chr20_+_42007949 1.021 NM_001098798
TOX2
TOX high mobility group box family member 2
chr17_+_7402315 1.018 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr10_+_102748062 1.016 LZTS2
leucine zipper, putative tumor suppressor 2
chr11_+_67532592 0.998 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr22_-_22970850 0.990 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr11_-_56846246 0.986 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr19_+_59941785 0.982 NM_015868
KIR2DS2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr1_+_31659246 0.975 NM_001199039
NM_018565
SERINC2

serine incorporator 2

chr5_+_148941228 0.968 NM_001001669
ARHGEF37
Rho guanine nucleotide exchange factor (GEF) 37
chr11_+_12917369 0.961 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr15_-_88148538 0.958 ANPEP
alanyl (membrane) aminopeptidase
chr12_+_52618815 0.957 NM_017410
HOXC13
homeobox C13
chr1_-_6502655 0.953 NM_198681
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr15_-_88148177 0.942 ANPEP
alanyl (membrane) aminopeptidase
chr2_-_192420168 0.938 NM_004657
SDPR
serum deprivation response
chrX_+_152423277 0.933 BGN
biglycan
chr1_-_171441234 0.922 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr15_-_88159061 0.918 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr10_+_685887 0.915 C10orf108
chromosome 10 open reading frame 108
chr12_-_8271460 0.914 NM_018088
FAM90A1
family with sequence similarity 90, member A1
chr5_-_176763991 0.912 F12
coagulation factor XII (Hageman factor)
chr1_+_84539876 0.911 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr9_+_101623957 0.907 NM_006981
NM_173199
NR4A3

nuclear receptor subfamily 4, group A, member 3

chr7_+_142788730 0.907 ZYX
zyxin
chr7_+_142789476 0.907 ZYX
zyxin
chr19_-_1046373 0.903 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr10_-_49993425 0.903 NM_001031746
NM_144984
C10orf72

chromosome 10 open reading frame 72

chr2_-_218551786 0.894 TNS1
tensin 1
chr20_+_8997660 0.886 NM_001172646
PLCB4
phospholipase C, beta 4
chr10_-_128067062 0.885 NM_003474
NM_021641
ADAM12

ADAM metallopeptidase domain 12

chr21_+_45699830 0.883 NM_030582
NM_130444
COL18A1

collagen, type XVIII, alpha 1

chr16_+_620932 0.883 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr16_-_85099941 0.874 LOC400550
hypothetical LOC400550
chr3_+_127743868 0.869 CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr17_+_7402788 0.869 TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr5_+_38481392 0.867 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr12_-_53099277 0.864 NM_002205
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_-_1046316 0.861 POLR2E
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr3_+_42675841 0.855 ZBTB47
zinc finger and BTB domain containing 47
chr1_-_23683214 0.847 ASAP3
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
chr9_+_115396020 0.847 NM_144489
RGS3
regulator of G-protein signaling 3
chr19_+_40849554 0.845 NM_007000
UPK1A
uroplakin 1A
chr14_-_22515725 0.844 JUB
jub, ajuba homolog (Xenopus laevis)
chr5_-_16989371 0.842 NM_012334
MYO10
myosin X
chr19_-_12807221 0.837 NM_031429
RTBDN
retbindin
chr17_-_74432671 0.837 TIMP2
TIMP metallopeptidase inhibitor 2
chr7_-_44071640 0.813 NM_000290
PGAM2
phosphoglycerate mutase 2 (muscle)
chr16_-_19803606 0.813 NM_016235
GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr1_+_107400789 0.812 NM_018137
PRMT6
protein arginine methyltransferase 6
chr8_+_144420939 0.809 NM_138465
GLI4
GLI family zinc finger 4
chr7_+_142723340 0.804 NM_000083
CLCN1
chloride channel 1, skeletal muscle
chr14_+_69021149 0.797 NM_001161498
UPF0639
UPF0639 protein
chr18_+_41558089 0.794 NM_001128588
NM_001146036
NM_015865
SLC14A1


solute carrier family 14 (urea transporter), member 1 (Kidd blood group)


chr7_-_5429702 0.792 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr1_+_175407153 0.792 NM_021165
FAM5B
family with sequence similarity 5, member B
chr16_-_30032330 0.790 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr1_-_27089371 0.786 NM_018066
GPN2
GPN-loop GTPase 2
chr5_-_172130766 0.783 NM_004417
DUSP1
dual specificity phosphatase 1
chr8_+_144366442 0.783 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr2_-_219404755 0.780 NM_017431
PRKAG3
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
chr1_+_1836125 0.778 NM_138705
CALML6
calmodulin-like 6
chr9_-_129679760 0.776 NM_000476
AK1
adenylate kinase 1
chr10_-_128066935 0.775 ADAM12
ADAM metallopeptidase domain 12
chr3_+_171621721 0.769 NM_001185056
CLDN11
claudin 11
chr9_-_129656830 0.768 NM_000118
NM_001114753
ENG

endoglin

chr6_-_31853027 0.768 NM_025258
C6orf27
chromosome 6 open reading frame 27
chr16_+_31391998 0.762 NM_015927
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr1_-_171286634 0.758 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr20_+_19903778 0.742 RIN2
Ras and Rab interactor 2
chr9_-_23811808 0.741 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr6_-_47030492 0.741 NM_015234
GPR116
G protein-coupled receptor 116
chr5_+_176449156 0.739 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr14_-_60260211 0.738 NM_017420
SIX4
SIX homeobox 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.21 4.19e-02 GO:0032501 multicellular organismal process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.88 4.49e-08 GO:0044421 extracellular region part
1.53 3.81e-07 GO:0044459 plasma membrane part
1.50 1.17e-05 GO:0005576 extracellular region
1.29 1.04e-04 GO:0005886 plasma membrane
1.79 1.24e-04 GO:0005615 extracellular space
1.29 1.25e-04 GO:0071944 cell periphery
2.30 2.37e-04 GO:0005578 proteinaceous extracellular matrix
2.13 5.10e-04 GO:0031012 extracellular matrix
1.54 1.57e-03 GO:0031226 intrinsic to plasma membrane
1.51 5.69e-03 GO:0005887 integral to plasma membrane
1.91 1.26e-02 GO:0043005 neuron projection
1.13 4.07e-02 GO:0016020 membrane

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.64 5.65e-03 GO:0008083 growth factor activity
1.51 4.15e-02 GO:0005102 receptor binding
3.40 4.39e-02 GO:0030165 PDZ domain binding